Using viral load and epidemic dynamics to optimize pooled testing in resource-constrained settings

B Cleary, JA Hay, B Blumenstiel, M Harden… - Science translational …, 2021 - science.org
Virological testing is central to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) containment, but many settings face severe limitations on testing. Group testing offers a …

[HTML][HTML] Group testing as a strategy for COVID-19 epidemiological monitoring and community surveillance

V Brault, B Mallein, JF Rupprecht - PLoS computational biology, 2021 - journals.plos.org
We propose an analysis and applications of sample pooling to the epidemiologic monitoring
of COVID-19. We first introduce a model of the RT-qPCR process used to test for the …

[HTML][HTML] Group testing via hypergraph factorization applied to COVID-19

D Hong, R Dey, X Lin, B Cleary, E Dobriban - Nature Communications, 2022 - nature.com
Large scale screening is a critical tool in the life sciences, but is often limited by reagents,
samples, or cost. An important recent example is the challenge of achieving widespread …

[HTML][HTML] Optimizing and evaluating PCR-based pooled screening during COVID-19 pandemics

J Yu, Y Huang, ZJ Shen - Scientific reports, 2021 - nature.com
Population screening played a substantial role in safely reopening the economy and
avoiding new outbreaks of COVID-19. PCR-based pooled screening makes it possible to …

Two-stage adaptive pooling with RT-qPCR for COVID-19 screening

A Heidarzadeh, K Narayanan - ICASSP 2021-2021 IEEE …, 2021 - ieeexplore.ieee.org
We propose two-stage adaptive pooling schemes, 2-STAP and 2-STAMP, for detecting
COVID-19 using real-time reverse transcription quantitative polymerase chain reaction (RT …

Safe and effective pool testing for SARS-CoV-2 detection

M Wunsch, D Aschemeier, E Heger, D Ehrentraut… - Journal of Clinical …, 2021 - Elsevier
Objectives The global spread of SARS-CoV-2 is a serious public health issue. Large-scale
surveillance screenings are crucial but can exceed test capacities. We (A) optimized test …

Group testing regression analysis with covariates and specimens subject to missingness

A Delaigle, R Tan - Statistics in Medicine, 2023 - Wiley Online Library
We develop parametric estimators of a conditional prevalence in the group testing context.
Group testing is applied when a binary outcome variable, often a disease indicator, is …

[HTML][HTML] Group testing with consideration of the dilution effect

H Jiang, H Ahn, X Li - Mathematics, 2022 - mdpi.com
We propose a method of group testing by taking dilution effects into consideration. We
estimate the dilution effect based on massively collected RT-PCR threshold cycle data and …

[HTML][HTML] Rapid design and implementation of an adaptive pooling workflow for SARS-CoV-2 testing in an NHS diagnostic laboratory: a proof-of-concept study

M Crone, P Randell, Z Herm, A Anand… - Wellcome Open …, 2021 - ncbi.nlm.nih.gov
Background: Diagnostic laboratories are currently required to provide routine testing of
asymptomatic staff and patients as a part of their clinical screening for SARS-CoV-2 …

PCR-Testkapazitäten nutzen für Personengruppen ohne Impfmöglichkeit: Serielles Screening von Kindern in KiTas und Grundschulen mittels Lolli-Pool-PCR …

J Seifried, S Böttcher, DY Oh, B Hauer, L Schaade… - 2021 - edoc.rki.de
In Folge der SARS-CoV-2-Pandemie ist es zu erheblichen Beeinträchtigungen des
regulären KiTa-und Schulbetriebs mit teilweise deutlichen Einschränkungen der …