Human oncoproteins promote transformation of cells into tumours by dysregulating the
signalling pathways that are involved in cell growth, proliferation and death. Although …

Understanding the cellular and molecular mechanisms of tumor initiation and progression
for each cancer type is central to making improvements in both prevention and therapy …

Healthy skin is a mosaic of wild-type and mutant clones,. Although injury can cooperate with
mutated Ras family proteins to promote tumorigenesis,,,,,,,,–, the consequences in …

As we age, our tissues are repeatedly challenged by mutational insult, yet cancer
occurrence is a relatively rare event. Cells carrying cancer-causing genetic mutations …

Cutaneous melanoma can be a most challenging neoplasm of high lethality, in part due to
its extreme heterogeneity and characteristic aggressive and invasive nature. Indeed, its …

Organs consist of multiple cell types that ensure proper architecture and function. How
different cell types coexist and interact to maintain their homeostasis in vivo remains elusive …

Normal tissues progressively acquire mutations. Some mutations are positively selected,
driving clonal expansions that may colonize the majority of a tissue by old age. In several …

Skin epithelial stem cells correct aberrancies induced by oncogenic mutations. Oncogenes
invoke different strategies of epithelial tolerance; while wild-type cells outcompete β-catenin …

The experimental need to engineer the genome both in time and space, has led to the
development of several photoactivatable Cre recombinase systems. However, the …

Defining the mechanisms that generate specialized cell types and coordinate their functions
is critical for understanding organ development and renewal. New tools and discoveries are …