The sense of smell collects vital information about the environment by detecting a multitude
of chemical odorants. Breadth and sensitivity are provided by a huge number of …

The mammalian genome possesses> 2000 olfactory receptor (OR) alleles regulated by 63
known OR-Enhancer elements, yet each olfactory sensory neuron (OSN) expresses only a …

Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which
lays the foundation for gametogenesis, totipotency, and embryonic development. We …

In mammals, each olfactory sensory neuron randomly expresses one, and only one,
olfactory receptor (OR)—a phenomenon called the “one‐neuron‐one‐receptor” rule …

Histone methylation and demethylation are important processes associated with the
regulation of gene transcription, and alterations in histone methylation status have been …

Transcription disequilibria are characteristic of many neurodegenerative diseases. The
activity-evoked transcription of immediate early genes (IEGs), important for neuronal …

An astounding property of the nervous system is its cellular diversity. This diversity, which
was initially realized by morphological and electrophysiological differences, is ultimately …

The olfactory sensory neurons are the only neurons in the mammalian nervous system that
not only regenerate naturally and in response to injury, but also project to specific targets in …

The senses provide a means by which data on the physical and chemical properties of the
environment may be collected and meaningfully interpreted. Sensation begins at the …

Cellular decision-making at the level of gene expression is a key process in the
development and evolution of every organism. Variations in gene expression can lead to …