Revisiting netrin-1: one who guides (axons)
NP Boyer, SL Gupton - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …
postsynaptic partners; this entails microns to meters of extension through an extracellular …
Syndecan receptors: pericellular regulators in development and inflammatory disease
The syndecans are the major family of transmembrane proteoglycans, usually bearing
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …
Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function
TML Cramer, B Pinan-Lucarre, A Cavaccini, A Damilou… - Cell Reports, 2023 - cell.com
The molecular code that controls synapse formation and maintenance in vivo has remained
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation
M Meier, M Gupta, S Akgül, M McDougall… - Nature …, 2023 - nature.com
Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular
processes including axon pathfinding, cell migration, adhesion, differentiation, and survival …
processes including axon pathfinding, cell migration, adhesion, differentiation, and survival …
Neural tissue homeostasis and repair is regulated via CS and DS proteoglycan motifs
Chondroitin sulfate (CS) is the most abundant and widely distributed glycosaminoglycan
(GAG) in the human body. As a component of proteoglycans (PGs) it has numerous roles in …
(GAG) in the human body. As a component of proteoglycans (PGs) it has numerous roles in …
Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury
Recent studies have revealed the heterogeneous nature of astrocytes; however, how
diverse constituents of astrocyte-lineage cells are regulated in adult spinal cord after injury …
diverse constituents of astrocyte-lineage cells are regulated in adult spinal cord after injury …
The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans
The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …
processes during development. In the past two decades, great progress has been made in …
[HTML][HTML] GPC3-Unc5 receptor complex structure and role in cell migration
O Akkermans, C Delloye-Bourgeois, C Peregrina… - Cell, 2022 - cell.com
Neural migration is a critical step during brain development that requires the interactions of
cell-surface guidance receptors. Cancer cells often hijack these mechanisms to disseminate …
cell-surface guidance receptors. Cancer cells often hijack these mechanisms to disseminate …
The CNS/PNS extracellular matrix provides instructive guidance cues to neural cells and neuroregulatory proteins in neural development and repair
Background. The extracellular matrix of the PNS/CNS is unusual in that it is dominated by
glycosaminoglycans, especially hyaluronan, whose space filling and hydrating properties …
glycosaminoglycans, especially hyaluronan, whose space filling and hydrating properties …
Neural glycosylphosphatidylinositol-anchored proteins in synaptic specification
Glycosylphosphatidylinositol (GPI)-anchored proteins are a specialized class of lipid-
associated neuronal membrane proteins that perform diverse functions in the dynamic …
associated neuronal membrane proteins that perform diverse functions in the dynamic …