Sirtuins are NAD+-dependent protein deacylases/ADP-ribosyltransferases that have
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …

Progress in the field of mitochondrial biology in the past few years has shown that
mitochondrial activities go beyond bioenergetics. These new aspects of mitochondrial …

In the area of brain injury and neurodegenerative diseases, a plethora of experimental and
clinical evidence strongly indicates the promise of therapeutically exploiting the endogenous …

Mitochondrial dysfunction contributes to the pathophysiology of acute neurologic disorders
and neurodegenerative diseases. Bioenergetic failure is the primary cause of acute …

Stroke is deemed a worldwide leading cause of neurological disability and death, however,
there is currently no promising pharmacotherapy for acute ischemic stroke aside from …

Hypoxic/ischemic injury remains the most dreaded cause of neurological disability and
mortality. Despite the humbling experiences due to lack of promising therapy, our …

Ischemic preconditioning is an innate neuroprotective mechanism in which a sub-injurious
ischemic exposure increases the brain's ability to withstand a subsequent, normally injurious …

Ellagic acid (EA), a natural polyphenolic compound, has been proved to possess multiple
biological activities including alleviating ischemic-reperfusion (I/R) injury. The aim of this …

Cerebral ischemia and stroke are increasing in prevalence and are among the leading
causes of morbidity and mortality in both developed and developing countries. Despite the …

Abstract Aims: Peroxiredoxins (PRXs) are a newly characterized family of peroxide
scavenging enzymes that not only help maintain cellular redox homeostasis but also may …