β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia
in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and …

The generation of post-translational modifications (PTMs) in human proteins is a
physiological process leading to structural and immunologic variety in proteins, with …

Balanced chromosomal abnormalities (BCAs) represent a relatively untapped reservoir of
single-gene disruptions in neurodevelopmental disorders (NDDs). We sequenced BCAs in …

OBJECTIVE Pancreatic β-cells exposed to proinflammatory cytokines display alterations in
gene expression resulting in defective insulin secretion and apoptosis. MicroRNAs are small …

Posttranslational modifications of self-proteins play a substantial role in the initiation or
propagation of the autoimmune attack in several autoimmune diseases, but their …

Microparticles and exosomes are two of the most well characterized membrane-derived
microvesicles released either directly from the plasma membrane or released through the …

OBJECTIVE Cytokines contribute to pancreatic β-cell death in type 1 diabetes. This effect is
mediated by complex gene networks that remain to be characterized. We presently utilized …

The 78-kDa glucose-regulated protein (GRP78) is an ubiquitously expressed endoplasmic
reticulum chaperone, with a central role in maintaining protein homeostasis. Recently, an …

Tolerogenic dendritic cells (DC) that are maturation-resistant and locked in a semimature
state are promising tools in clinical applications for tolerance induction. Different …

The β-cell has become recognized as a central player in the pathogenesis of type 1 diabetes
with the generation of neoantigens as potential triggers for breaking immune tolerance. We …