The complexity of treating neurological diseases has meant that new strategies have had to
be developed to deliver drugs to the brain more efficiently and safely. Intranasal drug …

Meloxicam, a selective COX-2 inhibitor, has demonstrated clinical effectiveness in managing
inflammation and acute pain. Although available in oral and parenteral formulations such as …

Agomelatine (AGM) is a unique melatonergic antidepressant drug. However, it possesses
low aqueous solubility, first-pass metabolism, and reduced bioavailability. The aim of the …

In this present formulation study, vinpocetine-loaded nano-spray-dried polymeric micelles
were developed via nano-spray-drying. Three different mucoadhesive excipients were …

Orally administered amoxicillin is recommended as the first-line treatment of acute bacterial
rhinosinusitis (ABR) and given in a high-dose regimen. However, the risk of various systemic …

The current research aims to develop thermosensitive polymeric micelles loaded with
risperidone for nasal administration, emphasizing the added benefits of their …

The low efficacy of drug transportation from the bloodstream to specific tissues remains a
challenge in drug delivery to the central nervous system (CNS), primarily because of the …

This study aims to highlight the importance of choosing the appropriate co-polymer or co-
polymer mixed combinations in order to design value-added nasal dosage forms. Local …

Freeze-thawing is a method that has proven beneficial to achieve cross-linking without the
use of chemicals. In this study, the aim was to evaluate the applicability of our previously …