The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

TP53 is the most frequently mutated gene in human cancer. It encodes the tumor suppressor
protein p53, which suppresses tumorigenesis by acting as a critical transcription factor that …

Genetically engineered mouse models only capture a small fraction of the genetic lesions
that drive human cancer. Current CRISPR–Cas9 models can expand this fraction but are …

PURPOSE To examine the impact of TP53 gain-of-function (GOF) and non-GOF mutations
on prognosis of advanced pancreatic ductal adenocarcinoma (PDAC) among patients with …

Background TP53, encoding the tumor suppressor p53, is frequently mutated in various
cancers, producing mutant p53 proteins (mutp53) which can exhibit neomorphic, gain-of …

Missense mutations in the p53 tumor suppressor abound in human cancer. Common
(“hotspot”) mutations endow mutant p53 (mutp53) proteins with oncogenic gain of function …

Cancer is characterized by alterations that cause the over-proliferation of cells and
hyperactivation of signaling pathways. Alterations of signaling molecules dysregulate …

The master-key TP53 gene is a tumor suppressor that is mutated in more than 50% of
human cancers. Some p53 mutants lose their tumor suppressor activity and acquire new …

Simple Summary Currently, genomic databases offer a vast amount of information on
mutational profiles and records of statistically significant genetic associations with diseases …

Lead (Pb) intoxication is known to damage the proximal tubules of kidney. Autophagy and
apoptosis have been shown to be involved in a variety of renal injuries, but the underlying …