The Role of Macrophages in Staphylococcus aureus Infection

GR Pidwill, JF Gibson, J Cole, SA Renshaw… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

The case for modeling human infection in zebrafish

MC Gomes, S Mostowy - Trends in microbiology, 2020 - cell.com
Zebrafish (Danio rerio) larvae are widely recognized for studying host–pathogen interactions
in vivo because of their optical transparency, genetic manipulability, and translational …

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

S Feys, SM Gonçalves, M Khan, S Choi… - The Lancet …, 2022 - thelancet.com
Background Influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated
pulmonary aspergillosis (CAPA) affect about 15% of critically ill patients with influenza or …

Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction

JAF Sutton, OT Carnell, L Lafage, J Gray, J Biboy… - PLoS …, 2021 - journals.plos.org
Peptidoglycan is the major structural component of the Staphylococcus aureus cell wall, in
which it maintains cellular integrity, is the interface with the host, and its synthesis is targeted …

The pathogenesis and potential therapeutic targets in sepsis

W Zhang, H Jiang, G Wu, P Huang, H Wang, H An… - MedComm, 2023 - Wiley Online Library
Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …

[HTML][HTML] In situ sprayed hydrogels containing resiquimod-loaded liposomes reduce chronic osteomyelitis recurrence by intracellular bacteria clearance

L Tian, Z Tan, Y Yang, S Liu, Q Yang, Y Tu, J Chen… - Acta Biomaterialia, 2023 - Elsevier
At present, surgical debridement and systematic administration of antibiotics represent the
mainstay of treatment for chronic osteomyelitis. However, it is now understood that …

Autophagy regulation in teleost fish: A double-edged sword

Z Zhou, Y He, S Wang, Y Wang, P Shan, P Li - Aquaculture, 2022 - Elsevier
In the last two decades, autophagy has attracted considerable attention as a conserved
cellular self-digestion process that is essential for cells to maintain metabolism and energy …

Selective Host Cell Death by Staphylococcus aureus: A Strategy for Bacterial Persistence

D Missiakas, V Winstel - Frontiers in immunology, 2021 - frontiersin.org
Host cell death programs are fundamental processes that shape cellular homeostasis,
embryonic development, and tissue regeneration. Death signaling and downstream host cell …

Identification of kinase modulators as host-directed therapeutics against intracellular methicillin-resistant Staphylococcus aureus

RHGA van den Biggelaar, KV Walburg… - Frontiers in Cellular …, 2024 - frontiersin.org
The increasing prevalence of antimicrobial-resistant Staphylococcus aureus strains,
especially methicillin-resistant S. aureus (MRSA), poses a threat to successful antibiotic …

Evasion of host defenses by intracellular Staphylococcus aureus

KE Watkins, M Unnikrishnan - Advances in Applied Microbiology, 2020 - Elsevier
Staphylococcus aureus is one of the leading causes of hospital and community-acquired
infections worldwide. The increasing occurrence of antibiotic resistant strains and the high …