Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Highlights•Novel orthogonal and reversible CID systems confer multiple layers of
manipulation.•Caged dimerizers allow control of protein function with spatiotemporal …

INTRODUCTION Mammalian embryos frequently develop abnormally, resulting in
miscarriages and genetic disorders such as Down syndrome. The major cause for aberrant …

During metaphase, chromosome position at the spindle equator is regulated by the forces
exerted by kinetochore microtubules and polar ejection forces. However, the role of forces …

Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote
chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly …

Cholangiocarcinoma, originating from the biliary duct, represents a subset of liver cancer.
With about 8000 new cases of cholangiocarcinoma diagnosed annually in the US, these fall …

Proper organization of the mitotic spindle is key to genetic stability, but molecular
components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still …

Phagocytes engulf unwanted particles into phagosomes that then fuse with lysosomes to
degrade the enclosed particles. Ultimately, phagosomes must be recycled to help recover …

Epidermal growth factor (EGF) binding to its receptor (EGFR) activates several signaling
intermediates, including Akt, leading to control of cell survival and metabolism …

Errors in mitosis that cause chromosome missegregation lead to aneuploidy and
micronucleus formation, which are associated with cancer. Accurate segregation requires …