Although astrogliosis and microglia activation are characteristic features of multiple sclerosis
(MS) and other central nervous system (CNS) lesions the exact functions of these events are …

Vitamin K is a fat-soluble nutrient discovered in 1935 and its role in blood coagulation has
been thoroughly explored. In recent years, studies conducted in vitro and on animals …

The role of vitamin K in the nervous system has been somewhat neglected compared with
other physiological systems despite the fact that this nutrient was identified some 40 y ago …

Purpose: The receptor tyrosine kinase Axl has recently been identified as a critical element
in the invasive properties of glioma cell lines. However, the effect of Axl and its ligand growth …

Degenerative dementia is mainly caused by A lzheimer's disease and/or cerebrovascular
abnormalities. Disturbance of the intracellular calcium homeostasis is central to the …

Early brain injury (EBI) following subarachnoid hemorrhage (SAH) is characterized by rapid
development of neuron apoptosis and dysregulated inflammatory response. Microglia …

Background Alzheimer's disease is the leading cause of dementia worldwide. TAM receptor
tyrosine kinases (Tyro3, Axl, MerTK) are known for their role in engagement of phagocytosis …

Context: Alzheimer's disease (AD) is a devastating neurodegenerative disorder that affects
millions of elderly people worldwide. However, no efficient therapeutic method for AD has …

Historically discovered for its role in blood coagulation, there is now convincing evidence
that vitamin K has important actions in the nervous system. As a unique cofactor to the γ …

Gas6 is a γ-carboxylated ligand for the receptor tyrosine kinase Axl. Gas6-Axl interactions
can rescue endothelial cells from apoptosis, and this study examined the intracellular …