Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution

DA Maslov, FR Opperdoes, AY Kostygov, H Hashimi… - Parasitology, 2019 - cambridge.org
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts

LJ Morrison, PC Steketee, MD Tettey, KR Matthews - Virulence, 2023 - Taylor & Francis
African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …

Population genomics reveals the origin and asexual evolution of human infective trypanosomes

W Weir, P Capewell, B Foth, C Clucas, A Pountain… - elife, 2016 - elifesciences.org
Evolutionary theory predicts that the lack of recombination and chromosomal re-assortment
in strictly asexual organisms results in homologous chromosomes irreversibly accumulating …

The compatibility between Biomphalaria glabrata snails and Schistosoma mansoni: an increasingly complex puzzle

G Mitta, B Gourbal, C Grunau, M Knight… - Advances in …, 2017 - Elsevier
This review reexamines the results obtained in recent decades regarding the compatibility
polymorphism between the snail, Biomphalaria glabrata, and the pathogen, Schistosoma …

Reproductive clonality in protozoan pathogens—truth or artefact?

JD Ramírez, MS Llewellyn - Molecular ecology, 2014 - Wiley Online Library
The debate around the frequency and importance of genetic exchange in parasitic protozoa
is now several decades old. Recently, fresh assertions have been made that predominant …

[HTML][HTML] Evidence and importance of genetic exchange among field populations of Trypanosoma cruzi

LA Messenger, MA Miles - Acta Tropica, 2015 - Elsevier
Many eukaryotic pathogenic microorganisms that were previously assumed to propagate
clonally have retained cryptic sexual cycles. The principal reproductive mode of …

Discovery and genomic analyses of hybridization between divergent lineages of Trypanosoma congolense, causative agent of Animal African Trypanosomiasis

E Tihon, H Imamura, JC Dujardin… - Molecular …, 2017 - Wiley Online Library
Hybrid populations and introgressive hybridization remain poorly documented in pathogenic
micro‐organisms, as such that genetic exchange has been argued to play a minor role in …

[HTML][HTML] 25 years of African trypanosome research: From description to molecular dissection and new drug discovery

KR Matthews - Molecular and Biochemical Parasitology, 2015 - Elsevier
Abstract The Molecular Parasitology conference was first held at the Marine Biological
laboratory, Woods Hole, USA 25 years ago. Since that first meeting, the conference has …

African trypanosome strategies for conquering new hosts and territories: the end of monophyly?

J Lukeš, A Kachale, J Votýpka, A Butenko… - Trends in …, 2022 - cell.com
Trypanosoma brucei parasites are the causative agents of African trypanosomiasis in
humans, as well as surra, nagana, and dourine in animals. According to current widely used …

A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome

P Capewell, A Cooper, C Clucas, W Weir, A Macleod - Parasitology, 2015 - cambridge.org
Trypanosoma brucei is the causative agent of African sleeping sickness in humans and one
of several pathogens that cause the related veterinary disease Nagana. A complex co …