Depression is a devastating psychiatric disorder caused by a combination of genetic
predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular …

The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine
kinase, which senses and integrates several intracellular and environmental cues to …

Abstract Disrupted-in-Schizophrenia 1 (DISC1) is a gene known as a risk factor for mental
illnesses possibly associated with dopamine impairments. DISC1 is a scaffold protein …

During the critical developmental periods of childhood when neural plasticity is high,
exposure to early life stress (ELS) or trauma may lead to enduring changes in physiological …

Exposures to stress at all stages of development can lead to long-term behavioural effects,
in part through changes in the epigenome. This review describes rodent research …

The study of gene× environment, as well as epistatic interactions in schizophrenia, has
provided important insight into the complex etiopathologic basis of schizophrenia. It has also …

Bisphenol A (BPA) is a ubiquitous environmental chemical that has been linked to
behavioral differences in children and shown to impact critical neurodevelopmental …

Cognitive functions including social cognition improve significantly during adolescence, the
time period during which the brain typically handles a large volume of incoming information …

KPNA1 is a mediator of nucleocytoplasmic transport that is abundantly expressed in the
mammalian brain and regulates neuronal differentiation and synaptic function. De novo …

Schizophrenia is a polygenetic disorder whose clinical onset is often associated with
behavioral stress. Here, we present a model of disease pathogenesis that builds on our …