Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer
H Zhang, C Qin, C An, X Zheng, S Wen, W Chen, X Liu… - Molecular cancer, 2021 - Springer
Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …
Jennifer Doudna for the development of the Clustered regularly interspaced short …
CRISPR technologies for genome, epigenome and transcriptome editing
Our ability to edit genomes lags behind our capacity to sequence them, but the growing
understanding of CRISPR biology and its application to genome, epigenome and …
understanding of CRISPR biology and its application to genome, epigenome and …
Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases
CRISPR-Cas9 gene editing has emerged as a powerful therapeutic technology, but the lack
of safe and efficient in vivo delivery systems, especially for tissue-specific vectors, limits its …
of safe and efficient in vivo delivery systems, especially for tissue-specific vectors, limits its …
Biomaterial-assisted targeted and controlled delivery of CRISPR/Cas9 for precise gene editing
RISPR-Cas9 has exhibited enormous potential in gene therapy. It can perform genome
editing with single-nucleotide precision in various types of cell and tissue, providing a …
editing with single-nucleotide precision in various types of cell and tissue, providing a …
Advanced nanotheranostics of CRISPR/Cas for viral hepatitis and hepatocellular carcinoma
Liver disease, particularly viral hepatitis and hepatocellular carcinoma (HCC), is a global
healthcare burden and leads to more than 2 million deaths per year worldwide. Despite …
healthcare burden and leads to more than 2 million deaths per year worldwide. Despite …
Engineered nanomaterials to potentiate CRISPR/Cas9 gene editing for cancer therapy
Clustered regularly interspaced short palindromic repeats/associated protein 9
(CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple …
(CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple …
Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis
Tumor-positive resection margins after surgery can result in tumor recurrence and
metastasis. Although adjuvant postoperative radiotherapy and chemotherapy have been …
metastasis. Although adjuvant postoperative radiotherapy and chemotherapy have been …
Nanobiomaterial vectors for improving gene editing and gene therapy
SW Hu, T Ding, H Tang, H Guo, W Cui, Y Shu - Materials Today, 2023 - Elsevier
With the development of genome editing techniques, gene therapy is becoming a viable
option for the treatment of a variety of human diseases. Genome editing techniques mainly …
option for the treatment of a variety of human diseases. Genome editing techniques mainly …
CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing
F Zhou, X Yu, R Gan, K Ren, C Chen… - Nucleic acids …, 2023 - academic.oup.com
The CRISPR-Cas system is a highly adaptive and RNA-guided immune system found in
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting …
Surgical resection to achieve tumor-free margins represents a difficult clinical scenario for
patients with hepatocellular carcinoma. While post-surgical treatments such as …
patients with hepatocellular carcinoma. While post-surgical treatments such as …