Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs

S Pinheiro, EMC Pinheiro, EMF Muri… - Medicinal Chemistry …, 2020 - Springer
Abstract The [1, 2, 4] triazolo [1, 5-a] pyrimidines (TPs) comprise an important class of non-
naturally occurring small molecules that aroused the interest of researches. This scaffold is …

Recent advances in 1, 2, 4-triazolo [1, 5-a] pyrimidine chemistry

G Fischer - Advances in Heterocyclic Chemistry, 2019 - Elsevier
The review deals with the pharmaceutically and agrochemically important group of 1, 2, 4-
triazolo [1, 5-a] pyrimidines (TPs) and covers relevant literature published from about 2006 …

Synthesis, molecular modelling and evaluation of larvicidal efficacy of annulated Benzo[h]chromenes against Culex pipiens L. Larvae

MKF El-Sayed, MM Elshahawi, FSM Abu El-Azm… - Scientific Reports, 2024 - nature.com
A new series of substituted benzo [h] chromene, benzochromenopyrimidine, and
benzochromenotriazolopyrimidine derivatives were synthesized via chemical …

Synthesis of antimicrobial azoloazines and molecular docking for inhibiting COVID‐19

ZA Muhammad, TA Farghaly, I Althagafi… - Journal of …, 2021 - Wiley Online Library
Diverse new azoloazines were synthesized from the reaction of fluorinated hydrazonoyl
chlorides with heterocyclic thiones, 1, 8‐diaminonaphthalene, ketene aminal derivatives …

An exhaustive compilation on chemistry of triazolopyrimidine: A journey through decades

PK Singh, S Choudhary, A Kashyap, H Verma… - Bioorganic …, 2019 - Elsevier
The triazolopyrimidine scaffold represents one of the privileged structure in chemistry, and
there has been an increase in number of studies utilizing this scaffold and its derivatives …

Cytotoxicity, docking study of new fluorinated fused pyrimidine scaffold: Thermal and microwave irradiation synthesis

AMA Alnaja, TA Farghaly, HSA El-Zahabi… - Medicinal …, 2021 - benthamdirect.com
Background: Azolopyrimidines are imposed on the arena of drugs treated for cancer. The
urgent need to discover new selective anticancer agents, paved the way to explore the …

Recent Trend in the Chemistry of Triazolopyrimidines and their Applications

MA Salem, MS Behalo… - Mini-Reviews in Organic …, 2021 - ingentaconnect.com
This review deals with the synthetic methods, chemical reactions, and applications of
triazolopyrimidine derivatives. The synthetic methods and chemical reactions are subdivided …

A greener and efficient method for nucleophilic aromatic substitution of nitrogen-containing fused heterocycles

JF Campos, M Loubidi, MC Scherrmann… - Molecules, 2018 - mdpi.com
A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-
containing fused heterocycles with interesting biological activities has been developed in an …

Triazolopyrimidine derivatives: an updated review on recent advances in synthesis, biological activities and drug delivery aspects

AS Abdelkhalek, MS Attia… - Current Medicinal …, 2024 - ingentaconnect.com
Molecules containing triazolopyrimidine core showed diverse biological activities, including
anti-Alzheimer's, anti-diabetes, anti-cancer, anti-microbial, anti-tuberculosis, anti-viral, anti …

7-(Substituted amino)-5-methylthioazolo [1, 5-a] pyrimidines: Synthesis, cytotoxic properties in vitro and molecular docking

DN Lyapustin, DF Fayzullina, IV Marusich… - Tetrahedron …, 2024 - Elsevier
A method for the synthesis of new 7-(substituted amino)-5-methylthioazolo [1, 5-a]
pyrimidines has been developed. Based on the MTT test, IC 50 values were calculated for …