RA is a chronic systemic inflammatory disease that primarily affects the small joints of the
hands and feet, and results in a mean reduction in life expectancy of 3–10 years. RA is a …

For decades, variability in clinical efficacy of the widely used inflammatory bowel disease
(IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and …

Rheumatoid arthritis (RA) is a chronic autoimmune disorder and the treatment involves the
use of traditional and biological disease modifying anti-rheumatic drugs (DMARDs). Recent …

Introduction The N-acetylation polymorphism has been the subject of comprehensive
reviews describing the role of arylamine N-acetyltransferase 2 (NAT2) in the metabolism of …

As a regulatory cell death mode defined in recent years, Ferroptosis is mainly characterized
by increased intracellular free iron and the accumulation of lipid peroxides. Ferroptosis is …

Objectives: Describe the mechanism of action of sulfasalazine. Identify the adverse effects
and contraindications of sulfasalazine. Determine appropriate monitoring steps and toxicity …

Lung cancer is the leading cause of cancer-related death worldwide and has a high
incidence rate. N-Acetyltransferase 2 (NAT2) is a polymorphic xenobiotic enzyme, which can …

Differences in drug responses in individuals are partly due to genetic variations in
pharmacogenes, which differ among populations. Here, genome sequencing of 171 …

Smoking is a main risk factor for bladder cancer (BC). NAT2 is a drug-metabolizing enzyme
that catalyses the detoxification of many xenobiotics and carcinogens. Single nucleotide …

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder that can lead to severe
joint damage and is often associated with a high morbidity and disability. Disease-modifying …