Beyond the margins: real-time detection of cancer using targeted fluorophores

RR Zhang, AB Schroeder, JJ Grudzinski… - Nature reviews Clinical …, 2017 - nature.com
Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …

Management of biochemical recurrence after primary curative treatment for prostate cancer: a review

W Artibani, AB Porcaro, V De Marco, MA Cerruto… - Urologia …, 2018 - karger.com
How to manage patients with prostate cancer (PCa) with biochemical recurrence (BCR)
following primary curative treatment is a controversial issue. Importantly, this prostate …

Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: early outcomes from a randomised controlled phase 3 study

JW Yaxley, GD Coughlin, SK Chambers, S Occhipinti… - The Lancet, 2016 - thelancet.com
Background The absence of trial data comparing robot-assisted laparoscopic prostatectomy
and open radical retropubic prostatectomy is a crucial knowledge gap in uro-oncology. We …

Positive surgical margins in the 10 most common solid cancers

RK Orosco, VJ Tapia, JA Califano, B Clary… - Scientific reports, 2018 - nature.com
A positive surgical margin (PSM) following cancer resection oftentimes necessitates
adjuvant treatments and carries significant financial and prognostic implications. We sought …

AND-gate contrast agents for enhanced fluorescence-guided surgery

JC Widen, M Tholen, JJ Yim, A Antaris… - Nature biomedical …, 2021 - nature.com
Surgical resection of tumours requires precisely locating and defining the margins between
lesions and normal tissue. However, this is made difficult by irregular margin borders …

Retzius‐sparing robot‐assisted radical prostatectomy vs the standard approach: a systematic review and analysis of comparative outcomes

E Checcucci, A Veccia, C Fiori, D Amparore… - BJU …, 2020 - Wiley Online Library
Objectives To summarize the current evidence on Retzius‐sparing (RS)‐robot‐assisted
radical prostatectomy (RARP) and to compare its oncological, peri‐operative and functional …

Retzius-sparing versus standard robot-assisted radical prostatectomy: a comparative prospective study of nearly 500 patients

P Umari, C Eden, D Cahill, M Rizzo, D Eden… - The Journal of …, 2021 - auajournals.org
Purpose: We compared standard robot-assisted radical prostatectomy and Retzius-sparing
robot-assisted radical prostatectomy in a multicenter study using prospective patient …

Extraprostatic tumor extension: comparison of preoperative multiparametric MRI criteria and histopathologic correlation after radical prostatectomy

KJ Park, M Kim, JK Kim - Radiology, 2020 - pubs.rsna.org
Background There are no standardized and well-validated criteria for assessing the risk of
extraprostatic extension (EPE) of prostate cancer at preoperative multiparametric MRI …

Neoadjuvant 177Lu-PSMA-I&T radionuclide treatment in patients with high-risk prostate cancer before radical prostatectomy: a single-arm phase 1 trial

S Golan, M Frumer, Y Zohar, E Rosenbaum… - European Urology …, 2023 - Elsevier
Background High-risk localized prostate cancer (HRLPC) has a substantial risk of disease
progression despite local treatment. Neoadjuvant systemic therapy before definitive local …

[HTML][HTML] PSMA-targeting agents for radio-and fluorescence-guided prostate cancer surgery

YHW Derks, DWPM Löwik, JPM Sedelaar… - Theranostics, 2019 - ncbi.nlm.nih.gov
Despite recent improvements in imaging and therapy, prostate cancer (PCa) still causes
substantial morbidity and mortality. In surgical treatment, incomplete resection of PCa and …