Aneuploidy is linked to myriad diseases but also facilitates organismal evolution. It remains
unclear how cells overcome the deleterious effects of aneuploidy until new phenotypes …

Several ETS transcription factors are involved in the pathogenesis of human cancers by
different mechanisms. As gene copy number gain/amplification is an alternative mechanism …

This chapter discusses neoplastic karyotypes. It emphasizes the difference between primary
and secondary changes and address the questions of why, how, when, and where …

The challenge of identifying common expression signatures in cancer is well known,
however the reason behind this is largely unclear. Traditionally variation in expression …

Background With the advancement in high-throughput technologies, researchers can
simultaneously investigate gene expression and copy number alteration (CNA) data from …

Feline leukemia virus (FeLV) is horizontally transmitted among cats and causes a variety of
hematopoietic disorders. Five subgroups of FeLV, A to D and T, each with distinct receptor …

Gene expression (GE) levels have important biological and clinical implications. They are
regulated by copy number alterations (CNAs). Modeling the regulatory relationships …

Background Multiple myeloma (MM) is a malignant proliferation of plasma B cells. Based on
recurrent aneuploidy such as copy number alterations (CNAs), myeloma is divided into two …

Background microRNAs (miRNAs) represent a class of small (typically 22 nucleotides in
length) non-coding RNAs that can degrade their target mRNAs or block their translation …

Human genetic variability can be either alterations in the sequence of the genome or
structural alterations that do not affect the genome sequence. Copy Number Variants (CNV) …