Cell transplantation therapy for spinal cord injury

P Assinck, GJ Duncan, BJ Hilton, JR Plemel… - Nature …, 2017 - nature.com
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …

Time is spine: a review of translational advances in spinal cord injury: JNSPG 75th Anniversary Invited Review Article

JH Badhiwala, CS Ahuja, MG Fehlings - Journal of Neurosurgery: Spine, 2018 - thejns.org
Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical,
emotional, and economic consequences for patients, families, and society at large. Timely …

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury

CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized …

Therapeutic interventions after spinal cord injury

S Thuret, LDF Moon, FH Gage - Nature Reviews Neuroscience, 2006 - nature.com
Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

Current applications and future perspectives of artificial nerve conduits

X Jiang, SH Lim, HQ Mao, SY Chew - Experimental neurology, 2010 - Elsevier
Artificial nerve guide conduits have the advantage over autografts in terms of their
availability and ease of fabrication. However, clinical outcomes associated with the use of …

[HTML][HTML] Role of the lesion scar in the response to damage and repair of the central nervous system

H Kawano, J Kimura-Kuroda, Y Komuta… - Cell and tissue …, 2012 - Springer
Traumatic damage to the central nervous system (CNS) destroys the blood–brain barrier
(BBB) and provokes the invasion of hematogenous cells into the neural tissue. Invading …

Hydrogels and cell based therapies in spinal cord injury regeneration

RC Assunção-Silva, ED Gomes, N Sousa… - Stem cells …, 2015 - Wiley Online Library
Spinal cord injury (SCI) is a central nervous system‐(CNS‐) related disorder for which there
is yet no successful treatment. Within the past several years, cell‐based therapies have …

Autologous olfactory ensheathing cell transplantation in human spinal cord injury

F Feron, C Perry, J Cochrane, P Licina, A Nowitzke… - Brain, 2005 - academic.oup.com
Olfactory ensheathing cells transplanted into the injured spinal cord in animals promote
regeneration and remyelination of descending motor pathways through the site of injury and …

[HTML][HTML] Prolonged inflammation leads to ongoing damage after spinal cord injury

JM Kwiecien, W Dabrowski, B Dąbrowska-Bouta… - PloS one, 2020 - journals.plos.org
The pathogenesis of spinal cord injury (SCI) remains poorly understood and treatment
remains limited. Emerging evidence indicates that post-SCI inflammation is severe but the …

Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony …

SH Yoon, YS Shim, YH Park, JK Chung, JH Nam… - Stem …, 2007 - academic.oup.com
To assess the safety and therapeutic efficacy of autologous human bone marrow cell (BMC)
transplantation and the administration of granulocyte macrophage-colony stimulating factor …