Mechanisms of hepatocyte growth factor activation in cancer tissues
M Kawaguchi, H Kataoka - Cancers, 2014 - mdpi.com
Hepatocyte growth factor/scatter factor (HGF/SF) plays critical roles in cancer progression
through its specific receptor, MET. HGF/SF is usually synthesized and secreted as an …
through its specific receptor, MET. HGF/SF is usually synthesized and secreted as an …
Discovery of selective matriptase and hepsin serine protease inhibitors: useful chemical tools for cancer cell biology
VC Damalanka, Z Han, P Karmakar… - Journal of medicinal …, 2018 - ACS Publications
Matriptase and hepsin belong to the family of type II transmembrane serine proteases
(TTSPs). Increased activity of these and the plasma protease, hepatocyte growth factor …
(TTSPs). Increased activity of these and the plasma protease, hepatocyte growth factor …
Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets
FM Franco, DE Jones, PKW Harris, Z Han… - Bioorganic & Medicinal …, 2015 - Elsevier
Hepatocyte growth factor activator (HGFA), matriptase and hepsin are all S1 trypsin-like
serine endopeptidases. HGFA is a plasma protease while hepsin and matriptase are type II …
serine endopeptidases. HGFA is a plasma protease while hepsin and matriptase are type II …
Promoter Hypomethylation Is Responsible for Upregulated Expression of HAI‐1 in Hepatocellular Carcinoma
X Du, L Wu, MS Ur Rahman, X Teng, L Teng… - Disease …, 2019 - Wiley Online Library
An upregulated expression of hepatocyte growth factor activator inhibitor type 1 (HAI‐1) in
hepatocellular carcinomas (HCC) associates with poor prognosis, but the underlying …
hepatocellular carcinomas (HCC) associates with poor prognosis, but the underlying …
The Role of HAI-2 in the Intestine Depends on Its Correct Subcellular Targeting
N Huang - 2024 - search.proquest.com
The hepatocyte growth factor activator inhibitor 1 (HAI-1) and HAI-2 are two closely related
type I transmembrane Kunitz type serine protease inhibitors, that consist of two homologous …
type I transmembrane Kunitz type serine protease inhibitors, that consist of two homologous …
[PDF][PDF] The influence of epigenetic modifications on the expression of SPINT1 and SPINT2 in colorectal cancer cell lines
MC Schmidt - rucforsk.ruc.dk
Hepatocyte growth factor (HGF) has been implicated in carcinogenesis due to its mitogenic,
motogenic, and morphogenic activities. Its activator, hepatocyte growth factor activator …
motogenic, and morphogenic activities. Its activator, hepatocyte growth factor activator …