Background Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …

Generalized epilepsy affects 24 million people globally; at least 25% of cases remain
medically refractory. The thalamus, with widespread connections throughout the brain, plays …

Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …

Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels were for the first time
implicated in absence seizures (ASs) when an abnormal I h (the current generated by these …

Chronic cocaine exposure induces enduring neuroadaptations that facilitate motivated drug
taking. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to …

Hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channels are
proposed to be critical for cognitive function through regulation of synaptic integration …

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, expressed in a variety
of cell types and in all tissues, control excitation and rhythm. Since their discovery in neurons …

Severe cardiac arrhythmias developing in the course of seizures increase the risk of SUDEP
(sudden unexpected death in epilepsy). Hence, epilepsy patients with pre-existing …

Prolonged exposure to opioids causes an enhanced sensitivity to painful stimuli (opioid-
induced hyperalgesia, OIH) and a need for increased opioid doses to maintain analgesia …

Ivabradine, a hyperpolarization-activated cyclic nucleotide–gated cation (HCN) channel
blocker and clinically approved bradycardic agent, has analgesic effects against …