Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material

Y Al Thaher, S Perni, P Prokopovich - Advances in colloid and interface …, 2017 - Elsevier
Total joint replacement (TJR), such as hip and knee replacement, is a popular procedure
worldwide. Prosthetic joint infections (PJI) after this procedure have been widely reported …

Local gentamicin delivery from resorbable viscous hydrogels is therapeutically effective

D Overstreet, A McLaren, F Calara… - Clinical Orthopaedics …, 2015 - journals.lww.com
Background Local delivery can achieve the high antimicrobial concentrations necessary to
kill biofilm-related microbes. Degradation times for resorbable carriers are too long …

A novel liposomal drug delivery system for PMMA bone cements

WN Ayre, JC Birchall, SL Evans… - Journal of Biomedical …, 2016 - Wiley Online Library
The population in developed countries is ageing and the number of people experiencing
joint‐related conditions, such as osteoarthritis, is expected to increase. Joint replacements …

Enhancing drug release from antibiotic-loaded bone cement using porogens

K Wu, YC Chen, YM Hsu… - JAAOS-Journal of the …, 2016 - journals.lww.com
Objective: To evaluate whether the addition of porogens to polymethyl methacrylate (PMMA)
enhances the antibiotic elution rate from antibiotic-loaded bone cement. Methods: Two …

Sustaining antibiotic release from a poly (methyl methacrylate) bone-spacer

P Oungeun, R Rojanathanes, P Pinsornsak… - Acs Omega, 2019 - ACS Publications
One of the challenges in using a bone-spacer to cure infection is the fabrication of a material
that can continuously release required antibiotics at effective concentrations for at least 4–6 …

Polymicrobial biofilm inhibition effects of acetate‐buffered chitosan sponge delivery device

JA Jennings, KE Beenken, AC Parker… - Macromolecular …, 2016 - Wiley Online Library
Polymicrobial biofilm‐associated implant infections present a challenging clinical problem.
Through modifications of lyophilized chitosan sponges, degradable drug delivery devices for …

载抗结核药物聚甲基丙烯酸甲酯骨水泥: 联合载药方案及抗结核效果

袁虎成, 石仕元, 马文鑫, 李旭生, 刘振, 马雪花 - 中国组织工程研究, 2018 - cjter.com
载抗结核药物聚甲基丙烯酸甲酯骨水泥:联合载药方案及抗结核效果 Page 1 《中国组织工程研究》
Chinese Journal of Tissue Engineering Research 文章编号:2095-4344(2018)34-05540-07 5540 …

Enhancement of Release Profile of Antibiotic from Antibiotic-Loaded Poly (methyl methacrylate) Bone Cement for Anchoring of Total Joint Arthroplasties: A State-of-the …

G Lewis - Essentials of Cemented Knee Arthroplasty, 2022 - Springer
The consensus is that periprosthetic joint infection (PJI) is the most devastating and
challenging complication of total joint arthroplasty. As such, many aspects of PJI have …

[PDF][PDF] Temperature-responsive hydrogels with controlled water content and their development toward drug delivery and embolization applications

D Overstreet - 2012 - core.ac.uk
Aqueous solutions of temperature-responsive copolymers based on N-isopropylacrylamide
(NIPAAm) hold promise for medical applications because they can be delivered as liquids …

PMMA and Antimicrobial Delivery

AC McLaren, CS Estes, R McLemore - … Joint Infection of the Hip and Knee, 2013 - Springer
Acrylic bone cement, poly (methyl methacrylate)(PMMA), is an acrylic polymer used in
orthopedic surgery primarily to fix prosthetic implants in bone. Since the early 1950s, cement …