Reactive oxygen species (ROS) are produced by living cells as normal cellular metabolic
byproduct. Under excessive stress conditions, cells will produce numerous ROS, and the …

The circadian clock is a complex cellular mechanism that, through the control of diverse
metabolic and gene expression pathways, governs a large array of cyclic physiological …

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been
retained throughout evolution such that it may be or may have been present in every species …

While melatonin is known to have protective effects in mitochondria‐related diseases, aging,
and neurodegenerative disorders, there is poor understanding of the effects of melatonin …

Melatonin, along with its metabolites, have long been known to significantly reduce the
oxidative stress burden of aging cells or cells exposed to toxins. Oxidative damage is a …

Reactive oxygen species (ROS) are mainly produced in mitochondria and are involved in
various physiological activities of the ovary through signaling and are critical for regulating …

Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation
is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N …

Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many
organs including the pineal gland, was initially characterized as a hormone primarily …

Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of
several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease …