Despite remarkable improvements in cancer treatment approaches, breast cancer is still the
main cause of cancer-related death in women. Its principal cause is the resistance of the …

Osteolytic bone disease is the hallmark of multiple myeloma, which deteriorates the quality
of life of myeloma patients, and it affects dramatically their morbidity and mortality. The basis …

Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …

Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …

In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong
regulation of cancer development and progression by the inflammation which orchestrates …

Over the last decade, there has been a growing interest in the role of mesenchymal stem
cells (MSC) in cancer progression. These cells have the potential to give rise to a variety of …

There is substantial evidence that many human cancers are driven by a subpopulation of
cells that display stem cell properties. These cancer stem cells (CSC) may also contribute to …

Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM).
More than 80% of MM patients suffer from destructive bony lesions, leading to pain …

The IL-6 family of cytokines comprises a large group of cytokines that all act via the formation
of a signaling complex that includes the glycoprotein 130 (gp130) receptor. Despite this …

Purpose: Deregulated expression of miRNAs has been shown in multiple myeloma (MM). A
promising strategy to achieve a therapeutic effect by targeting the miRNA regulatory network …