Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function

JD Rudolf, CY Chang, M Ma, B Shen - Natural Product Reports, 2017 - pubs.rsc.org
Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …

Homogeneous oxygenase catalysis

Y Liang, J Wei, X Qiu, N Jiao - Chemical reviews, 2018 - ACS Publications
Oxygenases-catalyzed reductive activation of molecular oxygen and incorporation of O
atoms into an organic molecule is undoubtedly one of the most attractive research areas …

Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae

F Zhao, P Bai, T Liu, D Li, X Zhang… - Biotechnology and …, 2016 - Wiley Online Library
Ginsenosides, the major bioactive components of Panax ginseng, are regarded as
promising high‐value pharmaceutical compounds. In ginseng, ginsenosides are produced …

[HTML][HTML] Rational and semi-rational engineering of cytochrome P450s for biotechnological applications

LH Xu, YL Du - Synthetic and systems biotechnology, 2018 - Elsevier
The cytochrome P450 enzymes are ubiquitous heme-thiolate proteins performing
regioselective and stereoselective oxygenation reactions in cellular metabolism. Due to their …

Semi‐rational engineering of cytochrome P450sca‐2 in a hybrid system for enhanced catalytic activity: insights into the important role of electron transfer

L Ba, P Li, H Zhang, Y Duan… - Biotechnology and …, 2013 - Wiley Online Library
Hybrid P450 systems in which P450 monooxygenases are reconstituted with non‐native or
surrogate redox partners have become important for the engineering of this class of versatile …

Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein

TS Chang - International Journal of Molecular Sciences, 2014 - mdpi.com
Daidzein and genistein are two major components of soy isoflavones. They exist abundantly
in plants and possess multiple bioactivities. In contrast, ortho-hydroxydaidzein (OHD) and …

Efficient hydroxylation of flavonoids by using whole-cell P450 sca-2 biocatalyst in Escherichia coli

B Hu, X Zhao, J Zhou, J Li, J Chen… - Frontiers in Bioengineering …, 2023 - frontiersin.org
The hydroxylation is an important way to generate the functionalized derivatives of
flavonoids. However, the efficient hydroxylation of flavonoids by bacterial P450 enzymes is …

Biosynthesis of the nylon 12 monomer, ω‐Aminododecanoic acid with novel CYP153A, AlkJ, and ω‐TA enzymes

MM Ahsan, H Jeon, S P. Nadarajan… - Biotechnology …, 2018 - Wiley Online Library
Bioplastics are derived from renewable biomass sources, such as vegetable oils, cellulose,
and starches. An important and high‐performance member of the bioplastic family is Nylon …

Catalytically self-sufficient cytochromes P450 for green production of fine chemicals

A Ciaramella, D Minerdi, G Gilardi - Rendiconti lincei, 2017 - Springer
This review covers our current knowledge on catalytically self-sufficient cytochromes P450.
These enzymes present all the advantages of the regio-and stereo-selectivity of typical …

Production of ω-hydroxy palmitic acid using CYP153A35 and comparison of cytochrome P450 electron transfer system in vivo

E Jung, BG Park, MM Ahsan, J Kim, H Yun… - Applied microbiology …, 2016 - Springer
Bacterial cytochrome P450 enzymes in cytochrome P450 (CYP) 153 family were recently
reported as fatty acid ω-hydroxylase. Among them, CYP153As from Marinobacter aquaeolei …