Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function
Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …
Homogeneous oxygenase catalysis
Y Liang, J Wei, X Qiu, N Jiao - Chemical reviews, 2018 - ACS Publications
Oxygenases-catalyzed reductive activation of molecular oxygen and incorporation of O
atoms into an organic molecule is undoubtedly one of the most attractive research areas …
atoms into an organic molecule is undoubtedly one of the most attractive research areas …
Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae
F Zhao, P Bai, T Liu, D Li, X Zhang… - Biotechnology and …, 2016 - Wiley Online Library
Ginsenosides, the major bioactive components of Panax ginseng, are regarded as
promising high‐value pharmaceutical compounds. In ginseng, ginsenosides are produced …
promising high‐value pharmaceutical compounds. In ginseng, ginsenosides are produced …
[HTML][HTML] Rational and semi-rational engineering of cytochrome P450s for biotechnological applications
LH Xu, YL Du - Synthetic and systems biotechnology, 2018 - Elsevier
The cytochrome P450 enzymes are ubiquitous heme-thiolate proteins performing
regioselective and stereoselective oxygenation reactions in cellular metabolism. Due to their …
regioselective and stereoselective oxygenation reactions in cellular metabolism. Due to their …
Semi‐rational engineering of cytochrome P450sca‐2 in a hybrid system for enhanced catalytic activity: insights into the important role of electron transfer
L Ba, P Li, H Zhang, Y Duan… - Biotechnology and …, 2013 - Wiley Online Library
Hybrid P450 systems in which P450 monooxygenases are reconstituted with non‐native or
surrogate redox partners have become important for the engineering of this class of versatile …
surrogate redox partners have become important for the engineering of this class of versatile …
Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein
TS Chang - International Journal of Molecular Sciences, 2014 - mdpi.com
Daidzein and genistein are two major components of soy isoflavones. They exist abundantly
in plants and possess multiple bioactivities. In contrast, ortho-hydroxydaidzein (OHD) and …
in plants and possess multiple bioactivities. In contrast, ortho-hydroxydaidzein (OHD) and …
Efficient hydroxylation of flavonoids by using whole-cell P450 sca-2 biocatalyst in Escherichia coli
The hydroxylation is an important way to generate the functionalized derivatives of
flavonoids. However, the efficient hydroxylation of flavonoids by bacterial P450 enzymes is …
flavonoids. However, the efficient hydroxylation of flavonoids by bacterial P450 enzymes is …
Biosynthesis of the nylon 12 monomer, ω‐Aminododecanoic acid with novel CYP153A, AlkJ, and ω‐TA enzymes
MM Ahsan, H Jeon, S P. Nadarajan… - Biotechnology …, 2018 - Wiley Online Library
Bioplastics are derived from renewable biomass sources, such as vegetable oils, cellulose,
and starches. An important and high‐performance member of the bioplastic family is Nylon …
and starches. An important and high‐performance member of the bioplastic family is Nylon …
Catalytically self-sufficient cytochromes P450 for green production of fine chemicals
This review covers our current knowledge on catalytically self-sufficient cytochromes P450.
These enzymes present all the advantages of the regio-and stereo-selectivity of typical …
These enzymes present all the advantages of the regio-and stereo-selectivity of typical …
Production of ω-hydroxy palmitic acid using CYP153A35 and comparison of cytochrome P450 electron transfer system in vivo
Bacterial cytochrome P450 enzymes in cytochrome P450 (CYP) 153 family were recently
reported as fatty acid ω-hydroxylase. Among them, CYP153As from Marinobacter aquaeolei …
reported as fatty acid ω-hydroxylase. Among them, CYP153As from Marinobacter aquaeolei …