Stroke is one of the major causes of disability and mortality worldwide. It is well known that
ischemic stroke can cause gray matter injury. However, stroke also elicits profound white …

The constant failure of new neuroprotective therapies for ischemic stroke has partially halted
the search for new therapies in recent years, mainly because of the high investment risk …

Biomarkers are measurable substances that could be used as objective indicators for
disease diagnosis, responses to treatments, and outcomes predictions. In this review, we …

Stroke research has traditionally focused on the cerebral processes following ischemic brain
injury, where oxygen and glucose deprivation incite prolonged activation of excitatory …

Glutamate excitotoxicity is a primary contributor of ischemic neuronal death and other
cellular components of the neurovascular unit. Several strategies have been developed …

Traumatic brain injury (TBI) is associated with significant cognitive and psychiatric
conditions. Neuropsychiatric symptoms can persist for years following brain injury, causing …

Stroke is the second highest reason of death in the world and the leading cause of disability.
The ischemic stroke makes up the majority of stroke cases that occur due to the blockage of …

Depression is a significant cause of disability and affects millions worldwide; however,
antidepressant therapies often fail or are inadequate. Current medications for treating major …

Brain insults are characterized by a multitude of complex processes, of which glutamate
release plays a major role. Deleterious excess of glutamate in the brain's extracellular fluids …

The concentration of the excitotoxic amino acid, L‐glutamate, in brain interstitial fluid is
tightly regulated by uptake transporters and metabolism in astrocytes and neurons. The aim …