Abstract γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid
organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By …

Trillions of microbes exist in the human body, particularly the gastrointestinal tract,
coevolved with the host in a mutually beneficial relationship. The main role of the intestinal …

IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the
prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues …

Summary T cell receptor (TCR) Vγ4-expressing γδ T cells comprise interferon γ (IFNγ)-and
interleukin-17 (IL-17)-producing effector subsets, with a preference for IL-17 effector fate …

Colorectal cancer is the third most common cancer worldwide with nearly 2 million cases per
year. Immune cells and inflammation are a critical component of colorectal cancer …

The γδ T cells play an important role in both mice and humans as a source of the cytokine IL‐
17, which is key for immune resistance to certain pathogens. In mice, most of these IL‐17 …

The mucosal surfaces of our body are the main contact site where the immune system
encounters non-self molecules from food-derived antigens, pathogens, and symbiotic …

Though macrophages and neutrophils are considered to be the principal immune cells
involved in gout inflammation, recent studies highlight an emerging role of T cell subsets in …

Little is known about how microbiota regulate innate-like γδ T cells or how these restrict their
effector functions within mucosal barriers, where microbiota provide chronic stimulation …

Cell survival, proliferation and function are energy-demanding processes, fuelled by
different metabolic pathways. Immune cells like any other cells will adapt their energy …