Microsecond Timescale Protein Dynamics: a Combined Solid‐State NMR Approach
Conformational exchange in proteins is a major determinant in protein functionality. In
particular, the μs–ms timescale is associated with enzymatic activity and interactions …
particular, the μs–ms timescale is associated with enzymatic activity and interactions …
Ligand entry into fatty acid binding protein via local unfolding instead of gap widening
Fatty acid binding proteins play an important role in the transportation of fatty acids. Despite
intensive studies, how fatty acids enter the protein cavity for binding is still controversial …
intensive studies, how fatty acids enter the protein cavity for binding is still controversial …
The observation of ligand-binding-relevant open states of fatty acid binding protein by molecular dynamics simulations and a Markov state model
Y Guo, M Duan, M Yang - International journal of molecular sciences, 2019 - mdpi.com
As a member of the fatty acids transporter family, the heart fatty acid binding proteins
(HFABPs) are responsible for many important biological activities. The binding mechanism …
(HFABPs) are responsible for many important biological activities. The binding mechanism …
On the Dynamic Mechanism of Long-Flexible Fatty Acid Binding to Fatty Acid Binding Protein: Resolving the Long-Standing Debate
H Chen, Y Guo, S Ye, J Zhang, H Zhang… - Journal of Chemical …, 2023 - ACS Publications
Fatty acids (FAs) are one of the essential energy sources for physiological processes, and
they play a vital role in regulating immune and inflammatory responses, promoting cell …
they play a vital role in regulating immune and inflammatory responses, promoting cell …
Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone
XC Yu, Y Hu, J Ding, H Li, C Jin - Journal of Biological Chemistry, 2019 - ASBMB
The role of protein structural disorder in biological functions has gained increasing attention
in the past decade. The bacterial acid-resistant chaperone HdeA belongs to a group of" …
in the past decade. The bacterial acid-resistant chaperone HdeA belongs to a group of" …
Effects of ligand binding on dynamics of fatty acid binding protein and interactions with membranes
Y Lu, GZ Yang, D Yang - Biophysical Journal, 2022 - cell.com
Intracellular transport of fatty acids involves binding of ligands to their carrier fatty acid
binding proteins (FABPs) and interactions of ligand-free and-bound FABPs with membranes …
binding proteins (FABPs) and interactions of ligand-free and-bound FABPs with membranes …
Conformational exchange of fatty acid binding protein induced by protein-nanodisc interactions
Fatty acid binding proteins (FABPs) can facilitate the transfer of long-chain fatty acids
between intracellular membranes across considerable distances. The transfer process …
between intracellular membranes across considerable distances. The transfer process …
Conformational flexibility differentiates naturally occurring Bet v 1 isoforms
S Grutsch, JE Fuchs, L Ahammer, AS Kamenik… - International Journal of …, 2017 - mdpi.com
The protein Bet v 1 represents the main cause for allergic reactions to birch pollen in Europe
and North America. Structurally homologous isoforms of Bet v 1 can have different properties …
and North America. Structurally homologous isoforms of Bet v 1 can have different properties …
Enhanced dynamics of conformationally heterogeneous T7 bacteriophage lysozyme native state attenuates its stability and activity
Proteins are dynamic in nature and exist in a set of equilibrium conformations on various
timescale motions. The flexibility of proteins governs various biological functions, and …
timescale motions. The flexibility of proteins governs various biological functions, and …
Brain fatty acid binding protein exhibits non-preferential and mutation-resistant binding towards fatty acids
I Bodnariuc, S Lenz, M Renaud-Young, TM Shandro… - BioRxiv, 2021 - biorxiv.org
Members of the fatty acid binding protein (FABP) family function as intracellular transporters
of long chain fatty acids and other hydrophobic molecules to different cellular compartments …
of long chain fatty acids and other hydrophobic molecules to different cellular compartments …