Microsecond Timescale Protein Dynamics: a Combined Solid‐State NMR Approach

P Rovó, R Linser - ChemPhysChem, 2018 - Wiley Online Library
Conformational exchange in proteins is a major determinant in protein functionality. In
particular, the μs–ms timescale is associated with enzymatic activity and interactions …

Ligand entry into fatty acid binding protein via local unfolding instead of gap widening

T Xiao, Y Lu, J Fan, D Yang - Biophysical journal, 2020 - cell.com
Fatty acid binding proteins play an important role in the transportation of fatty acids. Despite
intensive studies, how fatty acids enter the protein cavity for binding is still controversial …

The observation of ligand-binding-relevant open states of fatty acid binding protein by molecular dynamics simulations and a Markov state model

Y Guo, M Duan, M Yang - International journal of molecular sciences, 2019 - mdpi.com
As a member of the fatty acids transporter family, the heart fatty acid binding proteins
(HFABPs) are responsible for many important biological activities. The binding mechanism …

On the Dynamic Mechanism of Long-Flexible Fatty Acid Binding to Fatty Acid Binding Protein: Resolving the Long-Standing Debate

H Chen, Y Guo, S Ye, J Zhang, H Zhang… - Journal of Chemical …, 2023 - ACS Publications
Fatty acids (FAs) are one of the essential energy sources for physiological processes, and
they play a vital role in regulating immune and inflammatory responses, promoting cell …

Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone

XC Yu, Y Hu, J Ding, H Li, C Jin - Journal of Biological Chemistry, 2019 - ASBMB
The role of protein structural disorder in biological functions has gained increasing attention
in the past decade. The bacterial acid-resistant chaperone HdeA belongs to a group of" …

Effects of ligand binding on dynamics of fatty acid binding protein and interactions with membranes

Y Lu, GZ Yang, D Yang - Biophysical Journal, 2022 - cell.com
Intracellular transport of fatty acids involves binding of ligands to their carrier fatty acid
binding proteins (FABPs) and interactions of ligand-free and-bound FABPs with membranes …

Conformational exchange of fatty acid binding protein induced by protein-nanodisc interactions

Y Lu, D Yang - Biophysical Journal, 2021 - cell.com
Fatty acid binding proteins (FABPs) can facilitate the transfer of long-chain fatty acids
between intracellular membranes across considerable distances. The transfer process …

Conformational flexibility differentiates naturally occurring Bet v 1 isoforms

S Grutsch, JE Fuchs, L Ahammer, AS Kamenik… - International Journal of …, 2017 - mdpi.com
The protein Bet v 1 represents the main cause for allergic reactions to birch pollen in Europe
and North America. Structurally homologous isoforms of Bet v 1 can have different properties …

Enhanced dynamics of conformationally heterogeneous T7 bacteriophage lysozyme native state attenuates its stability and activity

M Sharma, N Jaiswal, D Kumar… - Biochemical Journal, 2019 - portlandpress.com
Proteins are dynamic in nature and exist in a set of equilibrium conformations on various
timescale motions. The flexibility of proteins governs various biological functions, and …

Brain fatty acid binding protein exhibits non-preferential and mutation-resistant binding towards fatty acids

I Bodnariuc, S Lenz, M Renaud-Young, TM Shandro… - BioRxiv, 2021 - biorxiv.org
Members of the fatty acid binding protein (FABP) family function as intracellular transporters
of long chain fatty acids and other hydrophobic molecules to different cellular compartments …