Tunneling nanotubes (TNTs), open membranous channels between connected cells,
represent a novel direct way of communication between distant cells for the diffusion of …

Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

Cell–cell fusion remains the least understood type of membrane fusion process. However,
the last few years have brought about major advances in understanding fusion between …

Skeletal muscle stem and progenitor cells including those derived from human pluripotent
stem cells (hPSCs) offer an avenue towards personalized therapies and readily fuse to form …

The dynamin GTPase is known to bundle actin filaments, but the underlying molecular
mechanism and physiological relevance remain unclear. Our genetic analyses revealed a …

ABSTRACT A characteristic of normal aging and age-related diseases is the remodeling of
the cellular organization of a tissue through polyploid cell growth. Polyploidy arises from an …

In epithelia, normal cells recognize and extrude out newly emerged transformed cells by
competition. This process is the most fundamental epithelial defence against cancer, whose …

The Dystrophin-Associated Protein Complex (DAPC) is a well-defined and evolutionarily
conserved complex in animals. DAPC interacts with the F-actin cytoskeleton via dystrophin …

Cell-cell fusion is a frequent and essential event during development, and its dysregulation
causes diseases ranging from infertility to muscle weakness. Fusing cells need to repeatedly …