The primary goals of positive end-expiratory pressure (PEEP) are to restore functional
residual capacity through recruitment and prevention of alveolar collapse. Through these …

Although the pathogenic and genetic basis of acute lung injury (ALI) remains incompletely
understood, the identification of novel ALI biomarkers holds promise for unique insights …

Acute respiratory distress syndrome (ARDS) consists of acute hypoxemic respiratory failure
characterized by massive and heterogeneously distributed loss of lung aeration caused by …

We investigated the value of procalcitonin kinetics as a prognostic marker during ventilator-
associated pneumonia (VAP). This prospective, observational study was conducted in a …

Objective: We tested whether the continuous monitoring of dynamic compliance could
become a useful bedside tool for detecting the beginning of collapse of a fully recruited lung …

Excessive mechanical stress is a key component of ventilator-associated lung injury,
resulting in profound vascular leak and an intense inflammatory response. To extend our in …

Rationale: The prone position is used to improve gas exchange in patients with acute
respiratory distress syndrome. However, the regional mechanism by which the prone …

Acute lung injury can be worsened by inappropriate mechanical ventilation, and numerous
experimental studies suggest that ventilator-induced lung injury is increased by excessive …

Objectives: It is not clear whether the mechanical properties of the respiratory system
assessed under the dynamic condition of mechanical ventilation are equivalent to those …

Purpose To determine whether, during mechanical ventilation, an optimal positive end-
expiratory pressure (PEEP) can be identified by measurement of regional tidal volume and …