In recent years, there has been increasing interest in using biomimetic materials for bone
tissue engineering. However, the high immunogenicity and low mechanical properties of …

Tissue engineering has emerged as a new treatment approach for bone repair and
regeneration seeking to address limitations associated with current therapies, such as …

Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic
loosening and infection are the two most significant causes of prosthetic implant failure. The …

The controlled delivery of growth factors and cells within biomaterial carriers can enhance
and accelerate functional bone formation. The carrier system can be designed with pre …

Growth factors are very promising molecules to enhance bone regeneration. However, their
translation to clinical use has been seriously limited, facing issues related to safety and cost …

Bone fracture followed by delayed or non-union typically requires bone graft intervention.
Autologous bone grafts remain the clinical “gold standard”. Recently, synthetic bone grafts …

Therapeutic approaches for musculoskeletal tissue regeneration commonly employ growth
factors (GFs) to influence neighboring cells and promote migration, proliferation, or …

Fibrinogen is one of the primary components of the coagulation cascade and rapidly forms
an insoluble matrix following tissue injury. In addition to its important role in hemostasis …

Over the past several decades, recombinant human bone morphogenetic proteins (rhBMPs)
have been the most extensively studied and widely used osteoinductive agents for clinical …

Polysaccharide nanocomposites have become increasingly important materials over the
past decade. Polysaccharides offer a green alternative to synthetic polymers in the …