Cytoskeletal structures characterized by actin filaments with uniform lengths, including the
thin filaments of striated muscles and the spectrin-based membrane skeleton, use barbed …

Actin is a profoundly influential protein; it impacts, among other processes, membrane
morphology, cellular motility, and vesicle transport. Actin can polymerize into long filaments …

Actin is a highly expressed protein in eukaryotic cells and is essential for numerous cellular
processes. In particular, efficient striated muscle contraction is dependent upon the precise …

Actin filaments are major components of the cytoskeleton in eukaryotic cells and are
involved in vital cellular functions such as cell motility and muscle contraction. Tmod and TM …

Tropomodulins (Tmods) are F-actin pointed end capping proteins that interact with
tropomyosins (TMs) and cap TM-coated filaments with higher affinity than TM-free filaments …

Leiomodin is a potent actin nucleator related to tropomodulin, a capping protein localized at
the pointed end of the thin filaments. Mutations in leiomodin-3 are associated with lethal …

Abstract The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal
muscle fibers. Since its discovery in 1988, the TPM3 gene has been recognized as an …

Tropomyosin (Tpm) binds along actin filaments and regulates myosin binding to control
muscle contraction. Tropomodulin binds to the pointed end of a filament and regulates actin …

The development of some familial dilated cardiomyopathies (DCM) correlates with the
presence of mutations in proteins that regulate the organization and function of thin filaments …

The formation and fine-tuning of cytoskeleton in cells are governed by proteins that influence
actin filament dynamics. Tropomodulin (Tmod) regulates the length of actin filaments by …