Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …

Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to
the development of organ-on-a-chip devices that can reproduce key functions of various …

The therapeutic efficacy of stem cells transplanted into an ischaemic brain depends primarily
on the responses of the neurovascular unit. Here, we report the development and …

Therapeutic options for neurological disorders currently remain limited. The intrinsic
complexity of the brain architecture prevents potential therapeutics from reaching their …

Ex vivo-loaded white blood cells (WBC) can transfer cargo to pathological foci in the central
nervous system (CNS). Here we tested affinity ligand driven in vivo loading of WBC in order …

An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering
to replicate the critical physiological environment and functions of the human organs …

Nanomedicine involves the use of engineered nanoscale materials in an extensive range of
diagnostic and therapeutic applications and can be applied to the treatment of many …

Highlights•Various approaches exist to recreate 2D and 3D structures of the
BBB.•Quantitative barrier functions in some BBB-chips are comparable to in vivo …

Microfluidics is an emerging technology that can be employed as a powerful tool for
designing lipid nano-microsized structures for biological applications. Those lipid structures …

The rapid advancement of genome editing technologies has opened up new possibilities in
the field of medicine. Nuclease-based techniques such as the CRISPR/Cas9 system are …