The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and
functional diversity and mediates a myriad of biological processes upon activation by …

Non-nutritive sweeteners (NNSs) elicit a multitude of endocrine effects in vitro, in animal
models, and in humans. The best-characterized consequences of NNS exposure are …

Except for the essential amino acids (AAs), much of the focus on adequate dietary protein
intake has been on total nitrogen and caloric intake rather than AA composition. Recent …

The oral detection of sugars relies on two types of receptor systems. The first is the G-protein-
coupled receptor TAS1R2/TAS1R3. When activated, this receptor triggers a downstream …

Diabetic kidney disease (DKD) has become a global health concern, with about 40% of
people living with type 1 and type 2 diabetes mellitus developing DKD. Upregulation of …

Background Eosinophilic inflammation is a hallmark of refractory chronic rhinosinusitis
(CRS) and considered a major therapeutic target. Autophagy deficiency in myeloid cells …

The consumption of artificial and low-calorie sweeteners (ASs, LCSs) is an important
component of the Western diet. ASs play a role in the pathogenesis of metabolic syndrome …

Low‐calorie sweeteners (LCS) are found in a variety of foods and beverages, yet their role
in diet, weight, and obesity‐related chronic disease is controversial. This article summarizes …

Amino acid sensing plays an important role in regulating lipid metabolism by sensing amino
acid nutrient disturbance. T1R1 (umami taste receptor, type 1, member 1) is a membrane G …

The special sense of taste guides and guards food intake and is essential for body
maintenance. Salty and sour tastes are sensed via ion channels or gated ion channels while …