[HTML][HTML] Natural products in drug discovery: advances and opportunities
AG Atanasov, SB Zotchev, VM Dirsch… - Nature reviews Drug …, 2021 - nature.com
Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …
Software tools and approaches for compound identification of LC-MS/MS data in metabolomics
The annotation of small molecules remains a major challenge in untargeted mass
spectrometry-based metabolomics. We here critically discuss structured elucidation …
spectrometry-based metabolomics. We here critically discuss structured elucidation …
Advances in decomposing complex metabolite mixtures using substructure-and network-based computational metabolomics approaches
Covering: up to the end of 2020 Recently introduced computational metabolome mining
tools have started to positively impact the chemical and biological interpretation of …
tools have started to positively impact the chemical and biological interpretation of …
Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics
Large-scale metabolite annotation is a challenge in liquid chromatogram-mass spectrometry
(LC-MS)-based untargeted metabolomics. Here, we develop a metabolic reaction network …
(LC-MS)-based untargeted metabolomics. Here, we develop a metabolic reaction network …
Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …
organisms and assess their biological properties from either a chemical ecology or drug …
Functional Traits 2.0: The power of the metabolome for ecology
A major aim of ecology is to upscale attributes of individuals to understand processes at
population, community and ecosystem scales. Such attributes are typically described using …
population, community and ecosystem scales. Such attributes are typically described using …
Recent advances in targeted and untargeted metabolomics by NMR and MS/NMR methods
K Bingol - High-throughput, 2018 - mdpi.com
Metabolomics has made significant progress in multiple fronts in the last 18 months. This
minireview aimed to give an overview of these advancements in the light of their contribution …
minireview aimed to give an overview of these advancements in the light of their contribution …
Recent developments along the analytical process for metabolomics workflows
We are in the midst of a shift in biological research paradigms from reductionist
methodologies that generate a hypothesis and rigorously and quantitatively measure the …
methodologies that generate a hypothesis and rigorously and quantitatively measure the …
Bioactive natural products prioritization using massive multi-informational molecular networks
Natural products represent an inexhaustible source of novel therapeutic agents. Their
complex and constrained three-dimensional structures endow these molecules with …
complex and constrained three-dimensional structures endow these molecules with …
Exploring the potential of a global emerging contaminant early warning network through the use of retrospective suspect screening with high-resolution mass …
A key challenge in the environmental and exposure sciences is to establish experimental
evidence of the role of chemical exposure in human and environmental systems. High …
evidence of the role of chemical exposure in human and environmental systems. High …