Advances in diagnosis and treatment of testicular cancer

M Chovanec, L Cheng - bmj, 2022 - bmj.com
Testicular cancer is a curable cancer. The success of physicians in curing the disease is
underpinned by multidisciplinary advances. Cisplatin-based combination chemotherapy and …

Molecular biomarkers with potential clinical application in testicular cancer

J Lobo, AM Acosta, GJ Netto - Modern Pathology, 2023 - Elsevier
Testicular germ cell tumors (TGCTs) and sex cord-stromal tumors (SCSTs) are the most
common testicular neoplasms. The morphological spectrum of such tumors is wide, with …

Detection of recurrence through microRNA-371a-3p serum levels in a follow-up of stage I testicular germ cell tumors in the DRKS-00019223 study

G Belge, C Dumlupinar, T Nestler, M Klemke… - Clinical Cancer …, 2024 - AACR
Purpose: Surveillance of clinical stage I (CSI) testicular germ cell tumors (GCT) is hampered
by low sensitivity and specificity of current biomarkers for detecting relapses. This study …

Prognostic factors for relapse in patients with clinical stage I testicular seminoma: a nationwide, population-based cohort study

T Wagner, BG Toft, J Lauritsen, M Bandak… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE Approximately 20% of patients with clinical stage I seminoma relapse. Tumor
size and rete testis invasion have been identified as risk factors for relapse. However, the …

Near-infrared photoimmunotherapy (NIR-PIT) in urologic cancers

H Fukushima, B Turkbey, PA Pinto, A Furusawa… - Cancers, 2022 - mdpi.com
Simple Summary Near-infrared photoimmunotherapy (NIR-PIT) is a novel molecularly-
targeted therapy that induces rapid cancer cell death by systemically administering an …

Testicular neoplasms: Primary tumour size is closely interrelated with histology, clinical staging, and tumour marker expression rates—A comprehensive statistical …

KP Dieckmann, H Isbarn, F Grobelny, C Dumlupinar… - Cancers, 2022 - mdpi.com
Simple Summary The size of the tumour is of clinical relevance in testicular tumours. Our
statistical analysis of 641 cases with testicular tumours revealed that 50% of cases with …

The role of CT in the staging and follow-up of testicular tumors: baseline, recurrence and pitfalls

T Pierre, F Selhane, E Zareski, C Garcia, K Fizazi… - Cancers, 2022 - mdpi.com
Simple Summary Testicular cancer (TC) is an uncommon group of tumors affecting
predominantly younger males between 15 and 40 years, and accounting for less than 1% of …

MicroRNA-371a-3p—The Novel Serum Biomarker in Testicular Germ Cell Tumors

T Nestler, J Schoch, G Belge, KP Dieckmann - Cancers, 2023 - mdpi.com
Simple Summary This review describes that miR371 is much more sensitive and specific
than the classical serum biomarkers of testicular germ cell cancer. There is a huge potential …

Outcomes of relapsed clinical stage I versus de novo metastatic testicular cancer patients: an analysis of the IGCCCG Update database

J Lauritsen, N Sauvé, A Tryakin, DM Jiang… - British journal of …, 2023 - nature.com
Background Active surveillance after orchiectomy is the preferred management in clinical
stage I (CSI) germ-cell tumours (GCT) associated with a 15 to 30% relapse rate. Patients …

Updates in 2022 on the staging of testicular germ cell tumors

SC Portillo, S Rais-Bahrami, C Magi-Galluzzi - Human Pathology, 2022 - Elsevier
Testicular cancer is the most common solid neoplasm of adult men between the ages of 20
and 40 years. Germ cell tumors account for 95% of all testicular tumors. The assessment of …