Molecular motors are protein machines whose directed movement along cytoskeletal
filaments is driven by ATP hydrolysis. Eukaryotic cells contain motors that help to transport …

The mechanics of the actomyosin interaction have been extensively studied using the
organized filament array of striated muscle. However, the extrapolation of these data to the …

A new in vitro assay using a feedback enhanced laser trap system allows direct
measurement of force and displacement that results from the interaction of a single myosin …

VISUALIZATION of single actin filaments by fluorescence microscopy1led to the
development of new in vitro assays for analysing actomyosin-based motility at the molecular …

Conventional kinesin is a motor protein that moves stepwise along microtubules carrying
membrane-bound organelles toward the periphery of cells. The steps are of amplitude 8.1 …

This book provides the reader with an account of some of the experimental evidence on
which our present knowledge is based. The third edition of this highly successful book has …

Actomyosin, a complex of actin filaments and myosin motor proteins, is responsible for force
generation during muscle contraction. To resolve the individual mechanical events of force …

We have developed a technique that allows mechanical and ligand-binding events in a
single myosin molecule to be monitored simultaneously. We describe how steps in the …

Skeletal muscle can bear a high load at constant length, or shorten rapidly when the load is
low. This force-velocity relationship is the primary determinant of muscle performance in …

THE MDM2 proto-oncogene is found amplified in a variety of tumours1. The oncogenic
capacity of the MDM2 protein is attributed to its ability to bind the p53 tumour-suppressor …