Epstein Barr virus: development of vaccines and immune cell therapy for EBV-associated diseases

X Cui, CM Snapper - Frontiers in Immunology, 2021 - frontiersin.org
Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated
in the etiology of multiple lymphoid and epithelial cancers. Each year EBV associated …

EBV-associated diseases: Current therapeutics and emerging technologies

S Chakravorty, B Afzali, M Kazemian - Frontiers in Immunology, 2022 - frontiersin.org
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …

Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice

V Dasari, LK McNeil, K Beckett, M Solomon… - Nature …, 2023 - nature.com
The recent emergence of a causal link between Epstein-Barr virus (EBV) and multiple
sclerosis has generated considerable interest in the development of an effective vaccine …

Immunotherapeutic approaches in EBV-associated nasopharyngeal carcinoma

W Li, X Duan, X Chen, M Zhan, H Peng… - Frontiers in …, 2023 - frontiersin.org
Epstein–Barr virus (EBV) was the first tumor virus in humans. Nasopharyngeal carcinoma
(NPC) accounts for approximately 60% of the 200,000 new tumor cases caused by EBV …

Targeting the signaling in Epstein–Barr virus-associated diseases: Mechanism, regulation, and clinical study

Y Cao, L Xie, F Shi, M Tang, Y Li, J Hu, L Zhao… - Signal transduction and …, 2021 - nature.com
Epstein–Barr virus-associated diseases are important global health concerns. As a group I
carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial-and …

Immunotherapy for nasopharyngeal carcinoma: Current status and prospects

H Huang, Y Yao, X Deng, Z Huang… - International …, 2023 - spandidos-publications.com
Nasopharyngeal carcinoma (NPC) is an epithelial tumor located in the nasopharynx and is
highly associated with Epstein‑Barr virus (EBV) infection. Although radiotherapy alone can …

Nasopharyngeal carcinoma: current views on the tumor microenvironment's impact on drug resistance and clinical outcomes

H Liu, L Tang, Y Li, W Xie, L Zhang, H Tang, T Xiao… - Molecular Cancer, 2024 - Springer
The incidence of nasopharyngeal carcinoma (NPC) exhibits significant variations across
different ethnic groups and geographical regions, with Southeast Asia and North Africa …

Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies

X Zheng, Y Huang, K Li, R Luo, M Cai, J Yun - Viruses, 2022 - mdpi.com
The Epstein–Barr virus (EBV) can cause different types of cancer in human beings when the
virus infects different cell types with various latent patterns. EBV shapes a distinct and …

Infectious mononucleosis: An updated review

AKC Leung, JM Lam, B Barankin - Current Pediatric Reviews, 2024 - ingentaconnect.com
Background: Infectious mononucleosis is common among adolescents and young adults.
Although the majority of cases resolve spontaneously, life-threatening manifestations, and …

mRNA‐based Vaccines Targeting the T‐cell Epitope‐rich Domain of Epstein Barr Virus Latent Proteins Elicit Robust Anti‐Tumor Immunity in Mice

GX Zhao, GL Bu, GF Liu, XW Kong, C Sun… - Advanced …, 2023 - Wiley Online Library
Epstein‐Barr virus (EBV) is associated with various malignancies and infects> 90% of the
global population. EBV latent proteins are expressed in numerous EBV‐associated cancers …