In their infection cycle, malaria parasites undergo replication and population expansions
within the vertebrate host and the mosquito vector. Host infection initiates with sporozoite …

Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

INTRODUCTION Plasmodium parasites, the causative agent of malaria, are single-celled
organisms with distinct morphological developmental stages each specialized to inhabit …

Malaria transmission requires that some asexual parasites convert into sexual forms termed
gametocytes. The initial stages of sexual development, including sexually committed …

The first obligatory phase of mammalian infection by Plasmodium parasites, the causative
agents of malaria, occurs in the liver of the host. This stage of Plasmodium infection bears …

The coordinated exit of intracellular pathogens from host cells is a process critical to the
success and spread of an infection. While phospholipases have been shown to play …

Plasmodium parasites have a complex life cycle alternating between a mosquito and a
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …

Pre-erythrocytic malaria vaccines target Plasmodium during its sporozoite and liver stages,
and can prevent progression to blood-stage disease, which causes a million deaths each …

The protozoan parasite Plasmodium is transmitted by female Anopheles mosquitoes and
undergoes obligatory development within a parasitophorous vacuole in hepatocytes before …

SUMMARY A wide spectrum of pathogenic bacteria and protozoa has adapted to an
intracellular life-style, which presents several advantages, including accessibility to host cell …