The role of Matrin-3 in physiology and its dysregulation in disease
ML Sprunger, ME Jackrel - Biochemical Society Transactions, 2024 - portlandpress.com
The dysfunction of many RNA-binding proteins (RBPs) that are heavily disordered, including
TDP-43 and FUS, are implicated in amyotrophic lateral sclerosis and frontotemporal …
TDP-43 and FUS, are implicated in amyotrophic lateral sclerosis and frontotemporal …
Sex differences in the relationship between depression and Alzheimer's disease—mechanisms, genetics, and therapeutic opportunities
YH Chen, ZB Wang, XP Liu, JP Xu… - Frontiers in Aging …, 2024 - frontiersin.org
Depression and Alzheimer's disease (AD) are prevalent neuropsychiatric disorders with
intriguing epidemiological overlaps. Their interrelation has recently garnered widespread …
intriguing epidemiological overlaps. Their interrelation has recently garnered widespread …
Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism
JM Kotah, MSJ Kater, N Brosens… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Early‐life stress (ES) increases the risk for Alzheimer's disease (AD). We
and others have shown that ES aggravates amyloid‐beta (Aβ) pathology and promotes …
and others have shown that ES aggravates amyloid‐beta (Aβ) pathology and promotes …
Detection of proteomic alterations at different stages in a Huntington's disease mouse model via matrix‐assisted laser desorption/ionization mass spectrometry (MALDI …
M Karayel‐Basar, I Uras, I Kiris… - European Journal of …, 2023 - Wiley Online Library
Huntington's disease (HD) is a progressive and irreversible neurodegenerative disease
leading to the inability to carry out daily activities and for which no cure exists. The …
leading to the inability to carry out daily activities and for which no cure exists. The …
Automated identification of protein expression intensity and classification of protein cellular locations in mouse brain regions from immunofluorescence images
LX Bao, ZM Luo, XL Zhu, YY Xu - Medical & Biological Engineering & …, 2024 - Springer
Abstract Knowledge of protein expression in mammalian brains at regional and cellular
levels can facilitate understanding of protein functions and associated diseases. As the …
levels can facilitate understanding of protein functions and associated diseases. As the …
Mapping the spatial proteomic signature of dorsal and ventral hippocampus in a mouse model of early Alzheimer's disease: changes in synaptic plasticity-related …
A Contreras, R Jimenez-Herrera, S Djebari… - bioRxiv, 2024 - biorxiv.org
Background: An initial neuropathological hallmark of Alzheimer's disease (AD) is the
hippocampal dysfunction caused by amyloid-β (Aβ) peptides accumulation. Soluble …
hippocampal dysfunction caused by amyloid-β (Aβ) peptides accumulation. Soluble …