Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

New therapies are required to reduce myocardial infarct (MI) size and prevent the onset of
heart failure in patients presenting with acute myocardial infarction (AMI), one of the leading …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

Adenosine is an endogenous nucleoside with a short half-life that regulates many
physiological functions involving the heart and cardiovascular system. Among the …

Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as
transmitter molecules, plays an essential role in immune system. In the extracellular …

Myocardial ischemia–reperfusion injury (IRI) leads to the stabilization of the transcription
factors hypoxia-inducible factor 1-alpha (HIF1-alpha) and hypoxia-inducible factor 2-alpha …

Nucleotides and nucleosides—such as adenosine triphosphate (ATP) and adenosine—are
famous for their intracellular roles as building blocks for the genetic code or cellular energy …

Despite increasing availability and more successful interventional approaches to restore
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …

Background: T cells are required for proper healing after myocardial infarction. The
mechanism of their beneficial action, however, is unknown. The proinflammatory danger …

Myocardial ischemia is associated with profound tissue hypoxia due to an imbalance in
oxygen supply and demand, and studies of hypoxia-elicited adaptive responses during …