The gene ontology knowledgebase in 2023
Abstract The Gene Ontology (GO) knowledgebase (http://geneontology. org) is a
comprehensive resource concerning the functions of genes and gene products (proteins …
comprehensive resource concerning the functions of genes and gene products (proteins …
[HTML][HTML] AlphaFold 2 and NMR spectroscopy: partners to understand protein structure, dynamics and function
DV Laurents - Frontiers in molecular biosciences, 2022 - frontiersin.org
The artificial intelligence program AlphaFold 2 is revolutionizing the field of protein structure
determination as it accurately predicts the 3D structure of two thirds of the human proteome …
determination as it accurately predicts the 3D structure of two thirds of the human proteome …
MobiDB: 10 years of intrinsically disordered proteins
The MobiDB database (URL: https://mobidb. org/) is a knowledge base of intrinsically
disordered proteins. MobiDB aggregates disorder annotations derived from the literature …
disordered proteins. MobiDB aggregates disorder annotations derived from the literature …
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
Abstract AlphaFold 2 (AF2) has placed Molecular Biology in a new era where we can
visualize, analyze and interpret the structures and functions of all proteins solely from their …
visualize, analyze and interpret the structures and functions of all proteins solely from their …
AlphaFold2 fails to predict protein fold switching
D Chakravarty, LL Porter - Protein Science, 2022 - Wiley Online Library
AlphaFold2 has revolutionized protein structure prediction by leveraging sequence
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …
BeStSel: webserver for secondary structure and fold prediction for protein CD spectroscopy
Circular dichroism (CD) spectroscopy is widely used to characterize the secondary structure
composition of proteins. To derive accurate and detailed structural information from the CD …
composition of proteins. To derive accurate and detailed structural information from the CD …
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …
proteins. For the majority of human proteins that contain intrinsically disordered regions …
Direct generation of protein conformational ensembles via machine learning
Dynamics and conformational sampling are essential for linking protein structure to
biological function. While challenging to probe experimentally, computer simulations are …
biological function. While challenging to probe experimentally, computer simulations are …
The 2022 Nucleic Acids Research database issue and the online molecular biology database collection
DJ Rigden, XM Fernández - Nucleic acids research, 2022 - academic.oup.com
Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …
87 papers reporting on new databases and 85 updates from resources previously published …
Intrinsic protein disorder and conditional folding in AlphaFoldDB
Intrinsically disordered regions (IDRs) defying the traditional protein structure–function
paradigm have been difficult to analyze. The availability of accurate structure predictions on …
paradigm have been difficult to analyze. The availability of accurate structure predictions on …