Coupled biological and chemical systems, neural networks, social interacting species, the
Internet and the World Wide Web, are only a few examples of systems composed by a large …

Attempts to correlate protein abundance with mRNA expression levels have had variable
success. We review the results of these comparisons, focusing on yeast. In the process, we …

Until recently, understanding the regulatory behavior of cells has been pursued through
independent analysis of the transcriptome or the proteome. Based on the central dogma, it …

Comprehensive protein–protein interaction maps promise to reveal many aspects of the
complex regulatory network underlying cellular function. Recently, large-scale approaches …

Protein complexes are key molecular entities that integrate multiple gene products to
perform cellular functions. Here we report the first genome-wide screen for complexes in an …

A versatile, platform independent and easy to use Java suite for large-scale gene
expression analysis was developed. Genesis integrates various tools for microarray data …

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that bind
as dimers to specific DNA target sites and that have been well characterized in nonplant …

The TRANSFAC® database on eukaryotic transcriptional regulation, comprising data on
transcription factors, their target genes and regulatory binding sites, has been extended and …

In apparently scale-free protein–protein interaction networks, or 'interactome'networks,, most
proteins interact with few partners, whereas a small but significant proportion of proteins, the …

Background Sequencing the genomes of multiple, taxonomically diverse eukaryotes
enables in-depth comparative-genomic analysis which is expected to help in reconstructing …