In recent years, multiparameter flow cytometry (MFC) immunophenotyping has become
mandatory in the clinical management of hematological malignancies, both for diagnostic …

Purpose To investigate the impact of immunophenotypic response (IR) versus complete
response (CR) and CR plus normal serum free light chain (sFLC) ratio (stringent CR) in …

The serum free light chain (FLC) assay is an important tool in the management of patients
with monoclonal gammopathies. MEDLINE®, the Cochrane Central Register of Controlled …

Novel and more effective treatment strategies against multiple myeloma (MM) have
significantly prolonged patients' survival and raised interest in the depth of response and its …

We analyzed 50 patients who achieved at least a very good partial response in the RV-MM-
EMN-441 study. Patients received consolidation with autologous stem-cell transplantation …

Purpose To clarify the impact of serum free light chain (sFLC) ratio normalization in patients
with multiple myeloma (MM) treated with novel agents. Patients and methods Treatment …

Multiparameter flow cytometry (MFC) and allele-specific oligonucleotide real-time
quantitative PCR (ASO RQ-PCR) are the two most sensitive methods to detect minimal …

Treatment of multiple myeloma has undergone substantial developments in the past 10
years. The introduction of novel drugs has changed the treatment of the disease and …

Organ dysfunction in light chain amyloidosis (AL) results from deposition of misfolded
monoclonal free light chains (FLC). A rapid reduction in FLC levels correlates with …

In 2000, the most important therapeutic improvement in multiple myeloma (MM) had been
the introduction of high-dose therapy (HDT) supported by autologous stem cell …