Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

In nature, organic molecules with great structural diversity and complexity are synthesized
by utilizing a relatively small number of starting materials. A synthetic strategy adopted by …

trans-syn-Fused drimane meroterpenoids are unique natural products that arise from contra-
thermodynamic polycyclizations of their polyene precursors. Herein we report the first total …

The aromatic polyketide 3, 5-dimethylorsellinic acid (DMOA) serves as a precursor for many
fungal meroterpenoids. A large portion of DMOA-derived meroterpenoids are …

3, 5-Dimethylorsellinic acid (DMOA)-derived spiromeroterpenoids are a unique natural
product family with attractive structures, unconventional stereochemistry, and potent …

Pyr4‐family terpene cyclases are noncanonical transmembrane terpene cyclases involved
in the biosynthesis of microbial meroterpenoids and catalyze diverse cyclization reactions …

Organic chemistry provides society with fundamental products we use daily. Concerns about
the impact that the chemical industry has over the environment is propelling major changes …

Capitalizing on the late‐stage diversification of an essential 1, 3‐diene intermediate, we
describe herein a 9‐step enantioselective total synthesis of (+)‐hyperforin and (+) …

Herein we report the first enantioselective total synthesis of 3, 5‐dimethylorsellinic acid‐
derived meroterpenoids (−)‐berkeleyone A and its five congeners ((−)‐preaustinoids A, A1 …

Prenyltransferases play important roles in the diversification of natural products and the
improvement of biological activities. A UbiA-type prenyltransferase CdnC with substrate …