CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance
mechanisms in autoreactive CD8 T cells. How autoimmune T cell populations arise and are …

Hematopoietic system (HS) is one of the most unique, adaptive and comprehensive
developmental systems on which various other body systems relies on. It consists of a …

The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that
when defective results in congenital heart disease (CHD). With current therapies, more than …

Immune responses in diverse tissue sites are critical for protective immunity and
homeostasis. Here, we investigate how tissue localization regulates the development and …

Brain region-specific degeneration and somatic expansions of the mutant Huntingtin (mHTT)
CAG tract are key features of Huntington's disease (HD). However, the relationships among …

MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by
Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating …

Pathogenic lymphocytes initiate the development of chronic inflammatory diseases. The
cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF)(encoded by Csf2) is a …

Hippo signaling is an evolutionarily conserved pathway that restricts growth and
regeneration predominantly by suppressing the activity of the transcriptional coactivator Yap …

Polyphosphates are linear polymers and ubiquitous metabolites. Bacterial polyphosphates
are long chains of hundreds of phosphate units. Here, we report that mouse survival of …

Wheat, an essential crop for global food security, is well adapted to a wide variety of soils.
However, the gene networks shaping different root architectures remain poorly understood …