Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

Kinesins are a family of molecular motors that travel unidirectionally along microtubule
tracks to fulfil their many roles in intracellular transport or cell division. Over the past few …

Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Accurate animal cell division requires precise coordination of changes in the structure of the
microtubule-based spindle and the actin-based cell cortex. Here, we use a series of …

Inducible degradation is a powerful approach for identifying the function of a specific protein
or protein complex. Recently, a plant auxin-inducible degron (AID) system has been shown …

Maintaining genome integrity during cell division requires regulated interactions between
chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct …

Before chromosomes segregate into daughter cells, they align at the mitotic spindle equator,
a process known as chromosome congression. Centromere-associated protein E (CENP …