Life, death and autophagy

J Doherty, EH Baehrecke - Nature cell biology, 2018 - nature.com
Autophagy influences cell survival through maintenance of cell bioenergetics and clearance
of protein aggregates and damaged organelles. Several lines of evidence indicate that …

Neutrophil extracellular traps (NETs) and damage‐associated molecular patterns (DAMPs): two potential targets for COVID‐19 treatment

S Cicco, G Cicco, V Racanelli… - Mediators of …, 2020 - Wiley Online Library
COVID‐19 is a pandemic disease caused by the new coronavirus SARS‐CoV‐2 that mostly
affects the respiratory system. The consequent inflammation is not able to clear viruses. The …

Autophagy induction promoted by m6A reader YTHDF3 through translation upregulation of FOXO3 mRNA

WC Hao, MJ Dian, Y Zhou, QL Zhong, WQ Pang… - Nature …, 2022 - nature.com
Autophagy is crucial for maintaining cellular energy homeostasis and for cells to adapt to
nutrient deficiency, and nutrient sensors regulating autophagy have been reported …

Autophagy—cell survival and death

X Yan, R Zhou, Z Ma - Autophagy: Biology and Diseases: Basic Science, 2019 - Springer
Autophagy, which is one of the most important ways to maintain cell homeostasis plays an
important regulatory role in cell survival and death. Currently, it is agreed that autophagy …

B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction

T Minato, S Nirasawa, T Sato, T Yamaguchi… - Nature …, 2020 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2) is critically involved in cardiovascular
physiology and pathology, and is currently clinically evaluated to treat acute lung failure …

Intersections between regulated cell death and autophagy

F Napoletano, O Baron, P Vandenabeele… - Trends in Cell …, 2019 - cell.com
In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the
spectrum of different forms of regulated cell death (RCD) has expanded dramatically with …

The regulatory properties of the Ccr4–Not complex

N Chalabi Hagkarim, RJ Grand - Cells, 2020 - mdpi.com
The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on
TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts …

m6A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis

Y Nagaki, S Motoyama, T Yamaguchi… - Genes to …, 2020 - Wiley Online Library
Esophageal squamous cell carcinoma (ESCC) is one of the most fatal types of malignant
tumors worldwide. Epitranscriptome, such as N6‐methyladenosine (m6A) of mRNA, is an …

Post-transcriptional dynamics and RNA homeostasis in autophagy and cancer

SP Kolapalli, TM Nielsen, LB Frankel - Cell Death & Differentiation, 2023 - nature.com
Autophagy is an essential recycling and quality control pathway which preserves cellular
and organismal homeostasis. As a catabolic process, autophagy degrades damaged and …

[HTML][HTML] The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy

A Pinard, S Guey, D Guo, AC Cecchi, N Kharas… - Genetics in …, 2020 - Elsevier
Purpose Moyamoya angiopathy (MMA) is a cerebrovascular disease characterized by
occlusion of large arteries, which leads to strokes starting in childhood. Twelve altered …