Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

The ethnomedical uses of Piper (胡椒Hú Jiāo) plants as anticancer agents, in vitro cytotoxic
activity of both extracts and compounds from Piper plants, and in vivo antitumor activity and …

Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on
the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of …

Antimicrobial natural preparations involving cinnamon, storax and propolis have been long
used topically for treating infections. Cinnamic acids and related molecules are partly …

Malignant transformation, driven by gain-of-function mutations in oncogenes and loss-of-
function mutations in tumour suppressor genes, results in cell deregulation that is frequently …

Identification and confirmation of bioactive small‐molecule targets is a crucial, often decisive
step both in academic and pharmaceutical research. Through the development and …

This article reviews new discoveries related to the phytochemistry and biological activities of
bioactive compounds from Piper species. It outlines the anticancer, anti-parasitic, and …

Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …

Piplartine (piperlongumine, 5, 6-dihydro-1-[(2E)-1-oxo-3-(3, 4, 5-trimethoxyphenyl)-2-
propenyl]-2 (1H)-pyridinone) is a biologically active alkaloid/amide from peppers, as from …