Obesity can profoundly alter pulmonary function and diminish exercise capacity by its
adverse effects on respiratory mechanics, resistance within the respiratory system …

Background The treatment of choice for moderate to severe obstructive sleep apnoea (OSA)
is continuous positive airways pressure (CPAP) applied via a mask during sleep. However …

Rationale: There is currently no effective pharmacological treatment for obstructive sleep
apnea (OSA). Recent investigations indicate that drugs with noradrenergic and …

In view of the high prevalence and the relevant impairment of patients with obstructive sleep
apnoea syndrome (OSAS) lots of methods are offered which promise definitive cures for or …

Excerpt The therapeutic effects of weight loss were evaluated in 15 hypersomnolent patients
with moderately severe obstructive sleep apnea. As patients decreased their body weight …

The National Commission on Sleep Disorders Research was established by Congress in
1988 “to conduct a comprehensive study of sleep disorders and to develop a long-range …

Background Hypoglossal nerve stimulation has been demonstrated to relieve upper airway
obstruction acutely, but its effect on obstructive sleep apnea is not known. Objective To …

Therapies for obstructive sleep apnea other than positive airway pressure, oral appliances,
and surgical modifications of the upper airway are reviewed in this practice parameter …

Nocturnal sleep studies of 12 patients with obstructive sleep apnea and a matched control
group of 12 subjects without the sleep apnea syndrome were analyzed to compare arterial …

Abbreviations: AHI= apnea! hypopnea index; CPAP= continuous positive airway pressure;
NREM= nonrapid eye movement; Pcrit= critical pressure; Pds= pressure downstream to the …